The reviewed papers showed that small peptides have selective cytotoxic effects through cell necrosis of tumour cells (GM15 and LfcinB(2025)4), strong ability to inhibit biofilm growth, eradicated pre-formed oral biofilms and showed efficient anti-biofilm activity in short-term exposures (DJK-5), regenerative action on human oral mucosal stem cells (CEMP1-p4), anti-inflammatory effect and differentiation characteristics of exogenous Pep-B in LPS-stimulated hDPSCs (Pep-B), Combined scaffolds for regenerating periodontal ligaments (RADA16), are involved in the mechanism by which gingiva grows (Ciclosporina A), bioregulators in the maintenance of homeostasis structural and functional homeostasis of cell populations (AEDG, KED)
The preservative-based formulation allows practitioners to prepare multiple doses from a single vial during a treatment session or across multiple appointments, improving workflow efficiency and cost management
GHK-Cu (regeneracja/ECM) vs Matrixyl / palmitoylo-GHK (matrikina pochodna)
These established therapies should generally be considered first-line treatments unless contraindicated or ineffective for individual patients
The published mechanistic literature has converged on the HGF/c-Met receptor system as the primary molecular target, with downstream effects on dendritic synaptogenesis and PI3K/AKT signaling
Freeze-thaw stress on a liquid peptide solution promotes aggregation and loss of bioactivity