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Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach belching constipation diarrhea stomach discomfort or upset Less common Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site Other side effects not listed may also occur in some patients

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Vascular complications represent the primary pathway

Nature 477 , 549555 (2011)

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GPCRs are important targets of drugs due to their ability to initiate cellular signaling pathways and their selective expression in target cells 11