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The methodology was flawed due to the employment of a highly subjective visual Taylor scale for pre- and post-treatment evaluation of change in skin hue and tone and lack of mention of statistical tests applied

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Children presenting neurological signs or symptoms, those unable to take oral medication, individuals with known malabsorption syndromes, infants under 6 months old, and patients using medications that may interfere with vitamin B12 absorption are typically treated with a parenteral protocol (1)

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The 42 amino acid peptides readily form oligomers that can further accumulate into fibrils and plaques in the brain, which are hallmarks of AD pathology (Cheignon et al., 2017

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