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But these findings are observational rather than from a randomized trial and thus need to be confirmed in other studies

they do not predict response to any specific compound

CONCLUSIONS CONFLICTS OF INTEREST No potential conflict of interest relevant to this article was reported

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

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It helps regulate blood glucose, increases glucose uptake into cells and slows the gastrointestinal, or GI, tract to maximize nutrient absorption