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Trulicity is one of several GLP-1 receptor agonist diabetes medications prescribed to treat type 2 diabetes and, in some cases, discussed alongside drugs marketed as a weight loss drug
GLP-1 RA-MWL leads to AT depletion, with associated skin laxity, volume loss, and accelerated aging, particularly in periorbital and midfacial regions
Adding the 9mg arm suggests the sponsor believes the 8mg to 12mg range contains the optimal therapeutic dose and wants more granular data to identify it precisely
dosing with 100 nmol kg 1 MK-801, 100 nmol kg 1 GLP-1, 100 nmol kg 1 GLP-1MK-801 or vehicle
Another study compared 11,046 tirzepatide users with the same number of semaglutide users