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Classical apoptosis remains the dominant mode of follicular loss: double-strand breaks trigger ATM/ATR-p53 signalling, up-regulating BAX/BAK and prompting mitochondrial outer-membrane permeabilisation with cytochrome-c release [78,79,80,81]

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One slightly reduced dose in a long-term protocol has negligible impact on overall results

That caveat established, the preclinical signal is unusually consistent across independent research groups and across a wide range of injury models, which is why the scientific conversation around BPC-157 continues to accelerate

Regular follow-up and monitoring of Vitamin B12 levels are essential to assess treatment effectiveness and ensure adequate management of the deficiency

PMC 6925818