Johny et al., 2019
PEGylation is the best modification for aptamer stability and half-life circulation in solid tumors with poorly vascularized regions with dense extracellular matrix that leads to slower drug uptake, such as lung, colon, and breast cancer (139)
These studies included fusions of the Fab to human albumin, to enable albumin:FcRn binding and grant the fusion protein albumin-like circulatory properties
Together, they charge and safeguard cells, allowing them to perform their functions
By encapsulating glutathione within protective liposomes, this innovative technology overcomes the limitations of traditional oral supplements, enhancing absorption, stability, and bioavailability
Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2