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Statistical significance was calculated by two-way ANOVA followed by multiple comparisons in a-b

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Adding 150 minutes of moderate-intensity exercise per week, or incorporating resistance training 2 to 3 times weekly, increases calorie expenditure and preserves lean muscle mass during weight loss

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In laboratory models, giving MOTS-c to sedentary animals produces exercise-like benefits it activates an exercise signal network that increases endurance and muscle capacity