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This incretin effect is considerably attenuated in people with type 2 diabetes (see Figure 1), a loss that is even considered an early indicator of the disease, but it was observed that this deficit could be completely corrected by the continuous infusion of GLP-1 to diabetic patients

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56: The need for repeated injections of somatostatin analogues throughout the day is a major limitation to the long-term administration of short-acting formulations Statement endorsed

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LaBar KS, Gitelman DR, Parrish TB, Kim YH, Nobre AC, Mesulam MM