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The analysis utilized data from the LEADER and SUSTAIN 6 cardiovascular outcome trials

The most commonly reported adverse effects in the trial were gastrointestinal in nature including nausea, diarrhoea, vomiting, and constipation which is consistent with the broader GLP-1 receptor agonist class

Microdosing may be appropriate for select patients, but it is not the right solution for everyone

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Gentler Appetite Control At sub-therapeutic amounts, retatrutide may still produce mild appetite suppression through its GLP-1 and GIP receptor activity