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The main difference between the mechanisms of action of the two drugs is that liraglutide only acts on the GLP-1 receptor, while tirzepatide is a co-agonist of GIPR next to the GLP-1R with a greater affinity to the GIPR [39]

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Customer Case Study: Quantification of Ketone Bodies by LCMS/MS and NMR in Human Plasma Background Methods Results Conclusions Accurate quantification of ketone bodies such as -hydroxybutyrate (-HB), acetoacetate (AcAc), and acetone is essential for studying mitochondrial fatty acid oxidation and energy metabolism

[1] The clinical trial data for semaglutide at the 2.4mg dose used in Wegovy did not identify menstrual irregularities or intermenstrual bleeding as a direct adverse effect of the medication