Many drugs look promising in cells, mice, or tissue samples but fail in later stages because: The treatment doesnt work well enough in humans It causes side effects at real doses The effect fades over time The human joint environment is much more complex than the lab So while we are hopeful, there is a long road ahead before this approach could become a real treatment
Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium
It is shocking that we have to turn to self- help
Some peptides, like GLP-1 agonists used for diabetes and obesity, are fda approved for specific indications
Ruenzi M, Stolte M, Veljaca M, Oreskovic K, Peterson J
TMAO concentrations correlate positively with various pathological conditions, including cardiovascular disease, diabetes, cancer, autoimmune disorders, bone metabolic diseases, polycystic ovary syndrome, and autism, while showing a negative correlation with conditions such as dementia and IBD (171)