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This review systematically examines metformins therapeutic mechanisms in PCOS management, while assessing its clinical impacts across critical developmental phasesfrom pubertal maturation through gestation to long-term health maintenance

The oral drug orforglipron (Foundayo) was also recently approved

10.1073/pnas.84.24.9265 139 IgnarroL

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A significantly decreases GSH levels in MC65 nerve cells, increases nonenzymatic and enzymatic oxidation of arachidonic acid (COX, 5-LOX, 12-LOX, and 15-LOX), and increases mitochondrial ROS levels and total intracellular lipid peroxides

Entry of Exendin-4 into brain is rapid but may be limited at high doses