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Graphical Abstract Access this article Similar content being viewed by others Abbreviations COX1: Cylco-oxygenase-1 COX2: Cylco-oxygenase-2 DT: Diphtheria toxin DTR: Diphtheria toxin receptor FBG: Fasting blood glucose GLP-1: Glucagon-like peptide-1 GSIS: Glucose-stimulated insulin secretion HFD: High-fat diet IAM: Islet-associated macrophage LPS: Lipopolysaccharide LPM: Large peritoneal macrophage PGE2: Prostaglandin E2 PM: Peritoneal macrophage qRT-PCR: Quantitative real-time PCR SPM: Small peritoneal macrophage VS: Valeryl salicylate WT: Wild-type References Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes

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For others, especially those with a history of restrictive eating, binge eating, body image distress, or disordered eating patterns, these medications require careful screening and medical supervision