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The force of water hitting the powder creates foaming, which introduces air into the solution and can denature the peptide through mechanical stress

Few investigations incorporated clinically relevant comparators, standardized rehabilitation conditions, or endpoints directly translatable to postoperative recovery

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However, the recommended range of 6.5 to 9.5 pH for tap water does reflect the reality that most systems try to keep their pH above 7 to minimize corrosion effects in their treatment plants and pipe distribution networks

2024;16(6):e13569

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