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Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice

GLP-1 RA treatment consistently reduced body weight, BMI, and waist circumference across all time points

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Pharmacokinetic analysis Plasma concentration-time profiles were analysed in C57BL6J mice and Sprague Dawley rats by a non-compartmental method using sparse sampling in Pharsight Phoenix WinNonLin v.6.4 software, and the resulting terminal half-life ( T 1/2 ), maximum plasma concentration ( C max ), time for maximum plasma concentration ( T max ), and AUC from zero to last valid measurable concentration-time point (AUC 0-t ) were determined

The failure was about lobbying weight and the legislative priority queue