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The observable maximal deuterium uptake of a peptide was calculated by the number of amino acid residues minus one (for the N-terminal residue) minus the number of proline residues

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Wilkes MC, Mitchell H, Penheiter SG, Dor JJ, Suzuki K, Edens M, et al

A total of 73 patients experienced treatment failure in the double-blind phase: 31 patients (45.6%) in the clonidine hydrochloride extended-release tablets group and 42 patients (62.7%) in the placebo group, with a statistically significant difference in the primary endpoint favoring clonidine hydrochloride extended-release tablets (Table 9)