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Participants receiving AOD-9604 maintained stable blood glucose levels, showed no changes in insulin sensitivity, demonstrated no alterations in HbA1c, and exhibited no increased risk of hyperglycemia or diabetic complications

(c) 3,4-dihydroxy groups located on the B-ring (denoted 3-4 site), resulting in a coordination similar to the catechol mode

Moreover, the activation of glia cells has been reported in both AD patients and animal models, accompanied by an activated complement system and increased levels of chemokines and cytokines [30,32,33,34,35]