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As the C-termini of all zDHHCs except zDHHC24 face the cytosol, we hypothesized that the addition of a C-terminal KASH-domain might induce their targeting to the ONM (Fig

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VIP delivery challenges The main limitation of VIP as a therapeutic peptide is its extremely short plasma half-life

doi: 10.1056/NEJM199404143301501

Shaped by a career that spans military service, anesthesiology, and advanced pain medicine, he is known for taking patients far beyond symptom relief, guiding them toward the strongest, most capable version of themselves