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SUSTAIN-6 was pivotal, revealing a 26% reduction in adverse heart outcomes

Cell 26 (15), 28582872

Update on Diabetes Mellitus and Glucose Metabolism Alterations in Prader-Willi Syndrome

In pre-clinical studies, GLP-1 mediated delivery of estrogen or dexamethasone has proven beneficial effects on glucose tolerance, bodyweight control and systemic inflammation (81)

Add a reduction in smoking, alcohol, and drugs for an even greater effect