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Diabetes Care 2005;28:89-94

Move from a 20% LAA serum to a 10% version, or switch to a vitamin C derivative that works at higher pH

The delivery of PDCs into tumor cells via tumor-homing peptides can exert a tumoricidal effect in the intracellular compartments of tumor cells where tumor-specific pH or enzymes can break the linkers, releasing the drugs

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After further examination of the included papers, the literature searches yielded a final result of 29 studies considered as relevant for the systematic review and 21 studies suitable for the meta-analyses

Cells were fixed with 4% paraformaldehyde (PFA), permeabilized with 0.2% Triton X-100, and then postfixed with 1% PFA + 0.01% Tween-20