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However, it has been demonstrated that this variant is not associated with venous thrombosis risk in the heterozygous state

Emerging data also point to benefits in conditions such as obstructive sleep apnea (OSA) and chronic kidney disease, including tirzepatide for moderate-to-severe OSA in adults with obesity and semaglutide for reducing kidney and cardiovascular risk in adults with CKD and T2D

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The program demonstrated biological activity but also identified cardiovascular effects that influenced development strategy

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