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10.1158/1078-0432.CCR-08-0230 80

What the Clinical Evidence Says About the Combination A randomized controlled trial published in the Journal of Cutaneous and Aesthetic Surgery comparing dermaroller monotherapy versus dermaroller combined with copper peptide for acne scars across 16 weeks produced findings that are clinically useful but deserve an honest reading

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The scoring function utilizes a sophisticated glide score that calculates both the empirical, as well as molecular mechanics energies and more accurate solvation and entropy methods

These effects were mediated through downstream activation of transcription factors including c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodelling, and angiogenic signalling

EMBO J 30:20442056 Mari M, Morales A, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC (2013) Mitochondrial glutathione: features, regulation and role in disease