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This dual agonist set the stage for the triple agonist concept behind Retatrutide

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GLP-1 receptor agonists also carry side effects particularly around appetite and nutrition that may be relevant in an oncology setting

Morales-Martinez, A., Dobrzynska, A

, Rikkunshito was effective in ameliorating upper GI symptoms, assessed by their scores on the Gastrointestinal Symptoms Rating Scale Questionnaire (56)

It is also involved in the transcriptional regulation of Nrf2 and the occurrence of oxidative stress