Intriguingly, a recent randomised controlled trial found that metformin significantly improved depressive symptoms in patients with treatment-resistant bipolar depression [134]
This ADI has been criticized for being much lower than scientific evidence would indicate is warranted . For example, it has been demonstrated that breast-fed infants consume 4.5 times more free glutamate than the EFSAs ADI. Finally, it has been pointed out that free glutamate and glutamate salts make only a marginal contribution to total dietary glutamate intake. While not all regulatory authorities agree on whether free glutamates should be limited, human studies have shown that extremely high levels of free glutamic acid (137 g per day) can be ingested for 30 days or longer with no ill effect. This is because our bodies are great at regulating the amount of glutamate in our blood
But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address
Song, Z., Mao, J., Barrero, R., Wang, P., Zhang, F., & Wang, T
Revised Sept 2019
[DOI] [PMC free article] [PubMed] [Google Scholar] Li J., Pei M
