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[12][13][17] Pulsatility matters: Research shows pulsatile GH release is preserved (and physiologically desirable) versus sustained elevation

Ann Endocrinol (Paris)

Our bodies change with age, making it harder to absorb Vitamin B12

Phase 1 breaks toxins down, and Phase 2 binds them to molecules so they can be safely eliminated

Metabolic factors influencing menstrual function during weight loss: Leptin levels: This adipocyte-derived hormone decreases with fat loss and plays a crucial role in reproductive function signaling Insulin sensitivity: Improved insulin sensitivity can normalize androgen levels, particularly beneficial in PCOS Inflammatory markers: Reduction in chronic low-grade inflammation associated with obesity Sex hormone-binding globulin (SHBG): Levels typically increase with weight loss, affecting free hormone availability For women with obesity-related reproductive dysfunction, particularly those with PCOS, moderate and sustained weight loss often improves menstrual regularity over time