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Undermethylation may represent one contributing or modifying pattern in a subgroup of patients

There is evidence to suggest that PPA are formed in healthy individuals at therapeutic doses, particularly following repeated doses, suggesting that not all NAPQI is scavenged by glutathione even during therapeutic administration (see Fig

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Moreover, we transfected 293T cells with Myc-labeled ubiquitin and Flag-labeled KEAP1 plasmids for further ubiquitination assay

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