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The brain regions most affected are the hypothalamus and brainstem, areas that regulate appetite and energy expenditure

In a 2023 Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al.), retatrutide produced 22.8% to 24.2% mean weight loss at 48 weeks at the higher doses (8 to 12 mg)

Navigating the Costs and Insurance Landscape Affordability and insurance coverage are critical factors when it comes to GLP-1 agonists

Gastrointestinal Distress Ozempic often causes side effects like nausea, vomiting, and indigestion, especially during the initial weeks of treatment

Because of the potential for fetal harm, discontinue WEGOVY in patients at least 2 months before they plan to become pregnant to account for the long half-life of semaglutide [see Use in Specific Populations (8.1)]

The autophagy mentioned in this article refers to macroautophagy