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Additionally, VX-765 specifically inhibits caspase-1, significantly attenuating the pro-pyroptotic and pro-fibrotic effects of the p-STAT3/ANXA2 axis [160]

Interpreting observational studies: why empirical calibration is needed to correct P values

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This not only enhances their inflammatory potential but also affects antigen processing, glutathionylation of signaling proteins, and interactions with resident CNS cells such as microglia and astrocytes (Federici et al., 2024)