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Dominant adaptive immune cell infiltration composed of B cells, CD4 + T cells and CD8 + T cells or ectopic lymphoid follicle-like structures were observed in the LSGs of patients with pSS

A comprehensive 2024 review in Diabetes Care confirmed that gastrointestinal symptoms remain among the most common limitations of GLP-1 therapy and the primary reason patients discontinue treatment

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The cold sensation experienced by many patients is likely multifactorial, involving changes in body composition, metabolic rate, and possibly other mechanisms that are not yet fully understood