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Consumption of a single dose greater than 7 g in an adult and 150 mg/kg in a child is considered potentially toxic to the liver and kidneys due to the highly active metabolite, N -acetyl- p -benzoquinone imine (NAPQI)[5]

These pro-inflammatory mediators subsequently recruit neutrophils and monocytes to the damaged area of the liver to trigger sterile inflammation

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But there is still little clinical research in dogs, and the use in a veterinary practice is still regarded as an investigational/off-label use

& Czaja, M

Gauron, C