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More evidence of NAD+'s significance in promoting mitochondrial and metabolic health may be seen in murine cells overexpressing the NADase CD38, which also had greater lactate levels, aberrant mitochondria, including missing or enlarged cristae, and lower oxygen consumption (7)

The expression of IR in the brain was analyzed semiquantitatively by western blotting

PloS One 11, e0141738

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However, there is no strong evidence in this area, recommending further investigations to clarify the possible adverse effects of riboflavin intake in high amounts