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The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4

How to Use: Administer subcutaneously under licensed medical supervision

It is water-soluble and absorbs relatively quickly from the injection site

For most people, this effect should fade within a few hours after the injection

Both are FDA-approved, self-administered once weekly, and require a prescription and physician supervision

APN5 Peptide Mechanism: APN5 peptide activates adiponectin receptors, mimicking the action of minoxidil but at a lower concentration