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There is no clinical data resolving that question

The reduction of the NADP pool suggests that the electron influx into the NADP pool by metabolism more than compensates for the electron efflux to the antioxidant systems, and that glutathione reductase activity, catalysing the reduction of glutathione from NADPH, is limiting under the specific conditions of reoxygenation after hypoxia

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1 This contrast suggests that duration of supplementation matters substantially