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In clinical trials, tirzepatide demonstrated weight reductions ranging from 15% to 22% of starting body weight over 68 weeks, depending on dose and individual response

Among them, the action of incretin hormones, known as the incretin effect, contributes to 50% to 70% of insulin secretion after the oral ingestion of glucose in healthy subjects [1]

Some patients lose weight rapidly in the first month, often partially from water and glycogen rather than pure fat loss

If that's worth it to you, Ritual makes a compelling case

Foundayo (Orforglipron) The latest entrant in the GLP-1 weight loss category is Foundayo, approved in April 2026

Helpful for working around my schedule without having to figure out the next steps alone