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contact a GP or trial team promptly for persistent vomiting, severe abdominal pain, or symptoms suggesting pancreatitis or gallbladder disease

Tests like GI-MAP or comprehensive stool panels can reveal useful information, but negative tests do not rule out significant clinical dysfunction

SURMOUNT-5 Head-to-Head In 2025, Eli Lilly published the SURMOUNT-5 trial directly comparing tirzepatide (15 mg) and semaglutide (2.4 mg) in adults with obesity over 72 weeks

The three-to-five year outlook for this category is very high

Timing matters significantly with oral semaglutide: you must take it on an empty stomach, 30 minutes before food or other medications, for optimal absorption