The target of glycated hemoglobin less than 5.7% (normoglycemia) was achieved in 27-46% of patients receiving tirzepatide compared to only 19% of those receiving semaglutide
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5), consistent with the results reported in cultured hippocampal neurons showing that acute application of GLP-1 induces a transient elevation of [Ca 2+ ] i [58]
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Multi-Receptor Co-Agonism Tirzepatide's superior clinical profile over semaglutide established that incremental receptor engagement can compound therapeutic value
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