Since the regulation of food intake through these complex processes of dynamic interactions between the homoeostatic and hedonic control systems and the higher-order regulatory adjustments functioned normally in the young animals used in our studies, which limits the direct applicability of these results to maladaptive eating behaviour or disorders in the regulation of feeding
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Discontinuation rates due to side effects in the highest-dose group were higher than semaglutide phase 2 data, suggesting tolerability may be a concern
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