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The heterodimer suppressed ROS (IC 50 = 18.79 M) and IL-6 (IC 50 = 4.15 M) production more effectively than celecoxib and diclofenac

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However, despite the plethora of observations regarding ROS and ATG, the only direct observation on the involvement of signal transduction mechanisms regulating self-digestion upon thiol/disulfide changes was evidenced in yeasts (Deffieu et al., 2009)