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The same process can happen elsewhere on the body, leading to loose skin on the arms, abdomen, thighs, buttocks, and neck

Least-squares mean percentage changes in body weight at week 48 were 8.7% (1 mg), 17.1% (4 mg), 22.8% (8 mg), and 24.2% (12 mg), compared with 2.1% in the placebo arm

But a year later investigators failed to reproduce their results which dampened enthusiasm to go any further (Moore

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This is a class effect shared across all GLP-1 receptor agonists , not a flaw in any particular medication

[11] [12] Those who believe they may benefit from emerging treatments like retatrutide in the future should discuss this with their GP or a specialist, who can advise on clinical trial eligibility or monitor developments in licensing