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This leads to dose-dependent weight loss (typically 8-15% in monotherapy trials), with additive effects when combined with GLP-1 agonists like semaglutide due to complementary mechanisms on energy balance and gastrointestinal function

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference

Constipation Paradoxically, some individuals experience constipation rather than diarrhea, likely related to delayed gastric emptying effects

Semaglutide alone: 5.1%

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