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A new real-world study reveals that advanced GLP-1 therapies, including semaglutide and tirzepatide, provide comparable glycemic control while offering superior weight benefits compared to metformin in adolescents newly diagnosed with type 2 diabetes

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Fisiopatologa y mecanismos de accin En pacientes normoglucmicos hay equilibrio entre clulas alfa (glucagn) y clulas beta (insulina) para lograr la homeostasia de glucosa ptima, pero en los pacientes con diabetes mellitus tipo 2 existe resistencia basal a la insulina que lleva a hiperinsulinemia, generando a largo plazo tolerancia a concentraciones altas de glucosa con dficit de insulina por prdida progresiva de clulas beta, as como por desdiferenciacin

Arch Biochem Biophys 726:109231

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