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The GLP-1-induced hyperpolarization of PVN neurons may be induced by an enhancement of inhibitory postsynaptic transmission (Liu et al., 2017)

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The balance between oxidative demand and redox buffering capacityas well as between catabolic drive and anabolic substrate supportmay therefore become an important determinant of tissue resilience and the durability of pharmacologically induced weight loss

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After reading about the triple agonist mechanism and seeing the trial data, I decided to give it a try