Systemic allergic symptoms require more urgent attention and include: Cutaneous manifestations : widespread urticaria (raised, itchy welts), generalised pruritus, flushing, or angioedema affecting the face, lips, tongue, or throat Respiratory symptoms : shortness of breath, wheezing, throat tightness, or stridor (high-pitched breathing sound) Gastrointestinal symptoms : nausea, vomiting, abdominal cramping, or diarrhoea (though these can also be common non-allergic side effects of GLP-1 agonists) Cardiovascular symptoms : dizziness, light-headedness, rapid or weak pulse, or feeling faint Anaphylaxis represents the most severe form of allergic reaction and is characterised by the rapid onset of symptoms affecting multiple organ systems
Notably, the high-dose 8 mg group achieved over 20% weight loss at 36 weeks through longer dose titration while keeping gastrointestinal toxicity manageable
What are the common side effects of GLP-1 agonists
This diversity is critical for understanding how retatrutide performs across different populations
All cited studies involve preclinical or in vitro models
Smoking reduces blood flow to oral tissues
