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This efficient reabsorption, combined with endogenous synthesis, typically prevents deficiency in healthy individuals

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But it can be rapidly exchanged to the free pool for entry into cells

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Importantly, overexpression of the wild-type (WT) AMPK1 catalytic subunit in shGDH1 cells not only increased cytosolic NADPH level and alleviated disulfide stress (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Campomanes P., Rothlisberger U., Alfonso-Prieto M., Rovira C