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Although patients receiving exenatide IR and experiencing longer durations of nausea and vomiting tended to lose more weight, those in the trial group who did not experience the gastrointestinal symptoms (70%) generally lost weight as well (166, 224)

Injection technique matters: pinch a fold of abdominal or thigh skin, insert at 90 degrees, inject steadily, count to ten before withdrawing

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in the New England Journal of Medicine , June 2023 [5][2]

Wegovy contains semaglutide and is approved specifically for weight management in the Australia (16), while Mounjaro acts on two hormone pathways (GLP-1 and GIP) and has demonstrated greater average weight loss in head-to-head clinical trials (17)

The drug works within the brain and gut circuits that regulate hunger and energy, and those circuits adapt to the medication