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doi: 10.1038/clpt.2014.187

132,133 Skeletal muscle tissue is the largest protein/amino acid (AA) reservoir in the human body, and lower muscle protein synthesis (MPS) induces fed-state anabolic resistance, 134 in addition to exercise training of the Akt/mTOR pathway

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And so let's say after 20 years, your body is habituated to the drugs that are no longer really working

Including both in your routine can help balance those benefits