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Furthermore, colonic mucosal damage in mice is associated with increased susceptibility to colitis, indicating the significant role of iron overload in the pathogenesis of colitis

R Franco, OJ Schoneveld, A Pappa, MI Panayiotidis

Constitutive activity was reversed by naloxone and naltrexone (proposed inverse agonists) but not the uniformly accepted neutral antagonist, 6 -naltrexol

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Topical application is limited by the stratum corneum barrier, with near-zero penetration through intact skin (Li et al., 2015)