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Targeting GLP-1R signaling represents an enormous translational opportunity as GLP-1 analogs are already available for clinical use

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-arrestin-bound GPCRs are targeted for endocytosis, which leads to dephosphorylation, re-sensitization and eventual receptor return to the plasma membrane, thus triggering receptor internalization, recycling and the modulation of additional signaling cascades by GPCRs (18)

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Its use in cosmetics is based on several decades of research and an excellent tolerability profile