18 When coupled with smaller and more infrequent meals, bile salt secretion into the intestine is decreased, reducing gallbladder motility and triggering the formation of biliary sludge, i.e., crystals or microliths composed of precipitated lipid particles
Future perspectives and outstanding questions Despite substantial progress, several unmet needs and key questions require investigation to fully realize the therapeutic potential of GLP-1-based therapies in MASLD/MASH
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This delayed gastric emptying means food remains in the stomach longer than usual, increasing the likelihood of gastrointestinal discomfort when consuming foods that are difficult to digest or that stimulate excessive gastric acid production
The patch pipette solution contained (in mM): 140 Cs-glutamate, 10 NaCl, 1 MgCl 2 , 0.2 EGTA, 2 MgATP, and 5 HEPES adjusted to pH 7.4 with CsOH
Hypoglycaemia is uncommon with GLP-1 monotherapy but can occur when combined with insulin or sulfonylureas
